abstract：BACKGROUND:Reversal of anticoagulation can be needed in patients undergoing heart valve surgery. ROTEM® has been correlated with international normalized ratio (INR) in patients on warfarin but not with patients on acenocoumarol. This study investigates the reliability of ROTEM® for detecting INR values below the 1.5 t...

journal_title：Thrombosis research

authors： Blasi A,Muñoz G,de Soto I,Mellado R,Taura P,Rios J,Balust J,Beltran J

更新日期：2015-09-01 00:00:00

abstract：INTRODUCTION:After major liver surgery, there are risks of both postoperative bleeding and thrombosis. Routine coagulation monitoring is indicated, but may not provide adequate clinical guidance. Thus, we described the clotting status in a pilot study using broader coagulation testing. We analysed the temporal pattern ...

journal_title：Thrombosis research

authors： Dumitrescu G,Januszkiewicz A,Ågren A,Magnusson M,Isaksson B,Wernerman J

更新日期：2015-08-01 00:00:00

abstract：INTRODUCTION:Inflammation and coagulation play important roles in the pathogenesis of sepsis. Anticoagulants with anti-inflammatory action draw attention as therapeutic agent in sepsis. OBJECTIVE:Whether cilostazol (6-[4-(1-cyclohexyl-1H-tetrazol-5-yl) butoxy]-3,4-dihydro-2-(1H)-quinolinone), anticoagulant, protects m...

journal_title：Thrombosis research

authors： Chang KC

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:The optimal prevention measures against hemodialysis (HD)-associated complications, including all-cause thrombotic events and death, are unclear. METHODS:This prospective study was designed to assess the effect of aspirin on prevention of HD-associated complications. Patients were divided into four groups a...

journal_title：Thrombosis research

authors： Yang Y,Wang C,Jin L,Chen G,Li C,Qi K,Kong D,Wang Y,Song M,Ma L

更新日期：2015-07-01 00:00:00

abstract：:Fibrinogen is a hexameric glycoprotein consisting of two sets of three polypeptides (the Aα, Bβ, and γ chains, encoded by the three genes FGA, FGB, and FGG). It is involved in the final phase of the coagulation process, being the precursor of the fibrin monomers necessary for the formation of the hemostatic plug. Rare...

journal_title：Thrombosis research

authors： Asselta R,Robusto M,Platé M,Santoro C,Peyvandi F,Duga S

更新日期：2015-07-01 00:00:00

abstract：INTRODUCTION:Dabigatran (Dabi) is not routinely monitored. However, in emergency cases quantitative assessment is required and laboratories must provide suitable tests at all hours. Little is known about Dabi effects on thrombin generation. MATERIALS AND METHODS:Patient samples (n=241) were analyzed for functional Dab...

journal_title：Thrombosis research

authors： Helin TA,Lemponen M,Hjemdahl P,Rönquist-Nii Y,Lassila R,Joutsi-Korhonen L

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:The Clauss fibrinogen method and thrombin clotting time (TCT) are still routinely used in patients with cirrhosis to define fibrinogen concentration and clotting potential. The thromboelastometric functional fibrinogen FIBTEM assay evaluates the strength of fibrin-based clots in whole blood, providing inform...

journal_title：Thrombosis research

authors： Vucelic D,Jesic R,Jovicic S,Zivotic M,Grubor N,Trajkovic G,Canic I,Elezovic I,Antovic A

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate the effect of CYP2C19 polymorphism and co-therapy with esomeprazole on the antiplatelet efficacy of clopidogrel. BACKGROUND:The antiplatelet efficacy of clopidogrel depends on CYP2C19 polymorphism or the co-administration of some kind of proton pump inhibitor (PPI). ...

journal_title：Thrombosis research

authors： Hokimoto S,Akasaka T,Tabata N,Arima Y,Tsujita K,Sakamoto K,Kaikita K,Morita K,Kumagae N,Yamamoto E,Oniki K,Nakagawa K,Ogawa H

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Postthrombotic intraluminal tissue causing postthrombotic syndrome (PTS) has not been well described. This study defines its histological characteristics and assess whether tissue function evolves over time. METHODS:Specimens from 18 common femoral veins (CFV) from 16 patients obtained during CFV endovenect...

journal_title：Thrombosis research

authors： Comerota AJ,Oostra C,Fayad Z,Gunning W,Henke P,Luke C,Lynn A,Lurie F

更新日期：2015-05-01 00:00:00

abstract：:The role of thrombin in vascular physiology and pathophysiology continues to impact our understanding of many cellular processes and systems including the function of platelets, endothelial cells, smooth muscle cells, leukocytes and the regulation of the coagulation cascade. Recent acute coronary syndrome clinical tri...

journal_title：Thrombosis research

authors： Giri S,Jennings LK

更新日期：2015-05-01 00:00:00

abstract：:VKORC1 and VKORC1L1 are enzymes that both catalyze the reduction of vitamin K2,3-epoxide via vitamin K quinone to vitamin K hydroquinone. VKORC1 is the key enzyme of the classical vitamin K cycle by which vitamin K-dependent (VKD) proteins are γ-carboxylated by the hepatic γ-glutamyl carboxylase (GGCX). In contrast, t...

journal_title：Thrombosis research

authors： Caspers M,Czogalla KJ,Liphardt K,Müller J,Westhofen P,Watzka M,Oldenburg J

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND/AIM:It is believed that the amniotic fluid-derived TF, in the case of amniotic fluid embolism (AFE), contributes to acute disseminated intravascular coagulation (DIC) and obstetric shock in the mother. However, the role of amniotic fluid-derived contact phase coagulation factors that irrupt into the bloodstr...

journal_title：Thrombosis research

authors： Uszyński W,Żekanowska E,Uszyński M,Kieszkowski P

更新日期：2015-04-01 00:00:00

abstract：INTRODUCTION:Fibrin structure and cellular composition of thrombi profoundly affect the clinical outcomes in ischemic coronary and peripheral artery disease. Our study addressed the interrelations of structural features of thrombi and routinely measured laboratory parameters. MATERIALS AND METHODS:Thrombi removed by t...

journal_title：Thrombosis research

authors： Kovács A,Sótonyi P,Nagy AI,Tenekedjiev K,Wohner N,Komorowicz E,Kovács E,Nikolova N,Szabó L,Kovalszky I,Machovich R,Szelid Z,Becker D,Merkely B,Kolev K

更新日期：2015-04-01 00:00:00

abstract：INTRODUCTION:Cell surface thiol isomerase enzymes, principally protein disulphide isomerase (PDI), have emerged as important regulators of platelet function and tissue factor activation via their action on allosteric disulphide bonds. Allosteric disulphides are present in other haemostasis-related proteins, and we have...

journal_title：Thrombosis research

authors： Smith CL,Shah CM,Kamaludin N,Gordge MP

更新日期：2015-04-01 00:00:00

abstract：INTRODUCTION:Von Willebrand Disease (VWD) is the most common inherited bleeding disorder. Measurement of von Willebrand factor (VWF) activity in plasma is often based on platelet agglutination stimulated by the ristocetin cofactor activity. Novel assays, based on latex beads with recombinant glycoprotein Ib instead of ...

journal_title：Thrombosis research

authors： Timm A,Hillarp A,Philips M,Goetze JP

更新日期：2015-04-01 00:00:00

abstract：INTRODUCTION:Rivaroxaban is an oral, selective direct factor Xa inhibitor approved for several indications in patients at risk of thrombotic events. One limitation of its clinical use is the lack of data pertaining to its reversal in situations where urgent response is critical (e.g. acute bleeding events or emergency ...

journal_title：Thrombosis research

authors： Herzog E,Kaspereit F,Krege W,Mueller-Cohrs J,Doerr B,Niebl P,Dickneite G

更新日期：2015-03-01 00:00:00

abstract：INTRODUCTION:Reports on the prevalence and risk factors of atherothrombotic events (AEs) are conflicting in persons with hemophilia (PWH). METHODS:This study evaluated the prevalence and risk factors of AEs among 1054 male hemophilia patients, using data collected from Taiwan's National Health Insurance Research Datab...

journal_title：Thrombosis research

authors： Wang JD,Chan WC,Fu YC,Tong KM,Chang ST,Hwang WL,Lin CH,Tsan YT

更新日期：2015-03-01 00:00:00

abstract：INTRODUCTION:Dabigatran etexilate is an oral direct thrombin inhibitor. Although routine anticoagulation monitoring with dabigatran is not usually required, a simple and precise laboratory test to measure dabigatran concentrations in patient plasma may be useful in certain clinical circumstances, such as emergency situ...

journal_title：Thrombosis research

authors： Schmohl M,Gansser D,Moschetti V,Stangier J

更新日期：2015-03-01 00:00:00

abstract：INTRODUCTION:Cancer is a major risk factor for developing venous thromboembolism (VTE). Plasma hypercoagulability is an established risk factor for cancer-related VTE. In addition, thrombocytosis and hyperreactive platelets have been implicated in VTE and cancer progression. Cirrhosis is associated with changes in plat...

journal_title：Thrombosis research

authors： Alkozai EM,Porte RJ,Adelmeijer J,Zanetto A,Simioni P,Senzolo M,Lisman T

更新日期：2015-02-01 00:00:00

abstract：:Antiphospholipid syndrome (APS) is an autoimmune disease characterized by arterial, venous or small-vessel thrombotic events, and recurrent miscarriages or fetal loss. APS diagnosis is based on the repeated detection of anti-phospholipid (PL) antibodies (Ab), typically associated with anti-β2 glycoprotein I (β2GPI)-Ab...

journal_title：Thrombosis research

authors： Cañas F,Simonin L,Couturaud F,Renaudineau Y

更新日期：2015-02-01 00:00:00

abstract：INTRODUCTION:Clinical trials have provided evidence about efficacy and safety of extended thromboprophylaxis among total hip replacement (THR) patients. There is a lack of evidence on effectiveness and safety of extended treatment in unselected patients from routine clinical practice. We examined the effectiveness and ...

journal_title：Thrombosis research

authors： Pedersen AB,Sorensen HT,Mehnert F,Johnsen SP,Overgaard S

更新日期：2015-02-01 00:00:00

abstract：INTRODUCTION:Data on efficacy and safety of using low molecular weight heparin in cancer patients with catheter-related upper extremity deep vein thrombosis is scarce and the risk of recurrent venous thromboembolism after discontinuation of anticoagulation is unknown. MATERIAL AND METHODS:We conducted a retrospective ...

journal_title：Thrombosis research

authors： Delluc A,Le Gal G,Scarvelis D,Carrier M

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:While post thrombotic syndrome (PTS) is increasingly recognized as a frequent and potentially serious complication of deep vein thrombosis (DVT) in children, limited information is available regarding predictors of PTS. METHODS:Using the Mayo Clinic Master Diagnostic Index, all pediatric patients (age 0 to ...

journal_title：Thrombosis research

authors： Kumar R,Rodriguez V,Matsumoto JM,Khan SP,Weaver AL,McBane RD,Beebe TJ,Heit JA

更新日期：2015-02-01 00:00:00

abstract：:Experience with tranexamic acid, an indirect fibrinolytic inhibitor, started as soon as it was released from Shosuke Okamoto's lab in the early 1960s. It was first prescribed to females with heavy menstrual blood loss and to patients with hereditary bleeding disorders. Soon the indications were widened to elective sur...

journal_title：Thrombosis research

authors： Tengborn L,Blombäck M,Berntorp E

更新日期：2015-02-01 00:00:00

abstract：:Cardiovascular disease (CVD) includes a number of conditions such as myocardial infarction, coronary heart disease, stroke, and venous thromboembolism. CVD is a leading health problem worldwide and a major cause of mortality, morbidity, and disability; it is also associated with high healthcare costs. The incidence of...

journal_title：Thrombosis research

authors： Cohen AT,Imfeld S,Markham J,Granziera S

更新日期：2015-02-01 00:00:00

abstract：:The brain and the placenta synthesize identical peptides and proteins, such as brain-derived neurotrophic factor, oxytocin, vascular endothelial growth factor, cortisol, and matrix metalloproteinases. Given the promiscuity between neurochemistry and the mechanism of placentation, it would be expected that mental disor...

journal_title：Thrombosis research

authors： Hoirisch-Clapauch S,Brenner B,Nardi AE

更新日期：2015-02-01 00:00:00

abstract：:The complex relation between thrombotic thrombocytopenic purpura (TTP) and pregnancy is concisely reviewed. Pregnancy is a very strong trigger for acute disease manifestation in patients with hereditary TTP caused by double heterozygous or homozygous mutations of ADAMTS13 (ADisintegrin And Metalloprotease with Thrombo...

journal_title：Thrombosis research

authors： von Auer C,von Krogh AS,Kremer Hovinga JA,Lämmle B

更新日期：2015-02-01 00:00:00

abstract：INTRODUCTION:Pulmonary embolism (PE) has a high morbidity and mortality. Hence it is important to recognize factors associated with higher risk of adverse outcomes in hemodynamically stable patients. Heart-type fatty acid binding protein (H-FABP) is a novel marker evaluated in recent years for prognosis in acute PE. Ou...

journal_title：Thrombosis research

authors： Liu M,Yuan X,Qiu X,Shan X,Lin D,Zhu L

更新日期：2015-01-01 00:00:00

abstract：:Numerous factors affect the response to vitamin K antagonists (VKA) including age, dietary vitamin K, other drugs, pharmacogenetics, and disease states. In antithrombotic guidelines, fever is mentioned as a factor that may increase response to VKA. The purpose of this article is to review the available evidence regard...

journal_title：Thrombosis research

authors： Self TH,Oliphant CS,Reaves AB,Richardson AM,Sands CW

更新日期：2015-01-01 00:00:00

abstract：:Generation of active Factor XII (FXIIa) triggers blood clotting on artificial surfaces and may also enhance intravascular thrombosis. We developed a patterned kaolin (0 to 0.3 pg/μm(2))/type 1 collagen fibril surface for controlled microfluidic clotting assays. Perfusion of whole blood (treated only with a low level o...

journal_title：Thrombosis research

authors： Zhu S,Diamond SL

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Acquired von Willebrand Syndrome is a rare bleeding disorder, which arises in individuals with no personal or family history of bleeding, associated with lymphoproliferative and myeloproliferative disorders or other diseases. AIM:To develop a two-step approach assay to detect autoantibodies against VWF and ...

journal_title：Thrombosis research

authors： Franchi F,Biguzzi E,Stufano F,Siboni SM,Baronciani L,Peyvandi F

更新日期：2014-12-01 00:00:00

abstract：:The reunification of Germany in 1990 brought with it major challenges in terms of unifying the care offered to haemophilia patients. At that time, most of the treatment centres belonged to the largest regional hospitals. The centre for paediatric haemophilia patients in Leipzig was at the University Hospital. In this ...

journal_title：Thrombosis research

authors： Lenk H

更新日期：2014-11-01 00:00:00

abstract：INTRODUCTION:High RDW values are associated with adverse prognosis in many clinical conditions including short and medium term outcome of patients with ST Elevation Myocardial Infarction (STEMI). The aim of the present study was to evaluate the association between RDW and long term mortality in STEMI patients undergoin...

journal_title：Thrombosis research

authors： Arbel Y,Shacham Y,Finkelstein A,Halkin A,Milwidsky A,Berliner S,Ziv-Baran T,Revivo M,Herz I,Keren G,Banai S

更新日期：2014-11-01 00:00:00

abstract：INTRODUCTION:There is some controversy regarding the effect of CYP2C19 polymorphism on clinical outcome in patients with dual antiplatelet therapy. Chronic kidney disease (CKD) is associated with increased risk of cardiovascular event, but the association between the possession of CYP2C19 loss-of-function (LOF) alleles...

journal_title：Thrombosis research

authors： Tabata N,Hokimoto S,Akasaka T,Arima Y,Kaikita K,Kumagae N,Morita K,Miyazaki H,Oniki K,Nakagawa K,Matsui K,Ogawa H

更新日期：2014-11-01 00:00:00

abstract：INTRODUCTION:Edoxaban is an oral, once-daily direct factor Xa (FXa) inhibitor. Although rapidly cleared, strategies to reverse edoxaban-mediated effects on anticoagulation are needed in cases of excessive bleeding or emergency. This study evaluated the effect of two prohemostatic agents, recombinant factor VIIa (rFVIIa...

journal_title：Thrombosis research

authors： Halim AB,Samama MM,Mendell J

更新日期：2014-10-01 00:00:00

abstract：INTRODUCTION:Bleeding after cardiac surgery may be caused by surgical factors, impaired haemostasis, or a combination of both. Transfusion of blood products is used to improve haemostasis, but little is known about what combination is optimal. We hypothesized that addition of both fibrinogen and platelets to blood samp...

journal_title：Thrombosis research

authors： Shams Hakimi C,Fagerberg Blixter I,Hansson EC,Hesse C,Wallén H,Jeppsson A

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVE:To characterize antithrombin (AT) levels in normal pregnancy. METHODS:We performed secondary analyses with data from 3 studies. Using a single measurement from each subject in the first analysis (cross-sectional), we correlated AT levels with gestational age from the middle of the second trimester throughout...

journal_title：Thrombosis research

authors： James AH,Rhee E,Thames B,Philipp CS

更新日期：2014-09-01 00:00:00

abstract：AIMS:acutely ill medical patients are at increased risk of venous thromboembolism (VTE) and often require thromboprophylaxis, but patient selection and adequate therapeutic decisions may be difficult due to the heterogeneity and the complexity of this population. We conducted a survey among a large cohort of Italian ph...

journal_title：Thrombosis research

authors： Dentali F,Pomero F,La Regina M,Orlandini F,Turato S,Mazzone A,Nozzoli C,Fontanella A,Ageno W,Agnelli G,Campanini M

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Few studies investigated the relationship between fibrinolysis abnormalities and residual pulmonary perfusion defects after acute pulmonary embolism (PE). OBJECTIVE:To assess the fibrinolytic profile in patients with prior PE in relation to the extent of scintigraphically detectable residual perfusion abnor...

journal_title：Thrombosis research

authors： Lami D,Cellai AP,Antonucci E,Fiorillo C,Becatti M,Grifoni E,Cenci C,Marcucci R,Mannini L,Miniati M,Abbate R,Prisco D

更新日期：2014-09-01 00:00:00

abstract：INTRODUCTION:Randomized clinical trials have demonstrated non-inferiority of rivaroxaban compared with vitamin K antagonists (VKAs) in the treatment of venous thromboembolism (VTE). Our objective was to analyze in real life, tolerance, recurrence, bleeding and adverse events of rivaroxaban in patients with acute sympto...

journal_title：Thrombosis research

authors： Jara-Palomares L,Sanchez-Oro-Gomez R,Elias-Hernandez T,Morillo-Guerrero R,Ferrer-Galvan M,Asensio-Cruz MI,Barrot-Cortes E,Otero-Candelera R

更新日期：2014-09-01 00:00:00